genotype and allele frequency of cyp2c19*17 in a healthy iranian population

نویسندگان

maryam payan biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

nader tajik immunology research center (irc), iran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)سازمان های دیگر: immunology research center (irc),

mohammad reza rouini biopharmaceutics and pharmacokinetics division, department of pharmaceutics, faculty of pharmacy, tehran university of med-ical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه تهران (tehran university)

mohammad hossein ghahremani department of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

چکیده

background: cytochrome p450 2c19 (cyp2c19) is important in metabolism of wide range of drugs. cyp2c19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (urm). distribution of this variant allele has not been well studied worldwide. the aim of present study was to investigate allele and genotype frequencies of cyp2c19*17 in a healthy iranian population and compare them with other ethnic groups.   methods : one hundred eighty healthy unrelated iranian volunteer took part in this study and were genotyped for cyp2c19 *2, *3, *17 (-3402) by using polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) and cyp2c19*17 (-806) by a nested-pcr assays. the distribution of cyp2c19*17 polymorphism in iranian population was then compared with other ethnic groups.   results : the cyp2c19*17 allele frequency was 21.6% in iranian population. among studied subjects 5.5% were homozygous for cyp2c19*17 and phenotyped as ultra-rapid metabolizers 28.8% were genotyped as cyp2c19*1*17 (extensive metabolizers) and 3.3% as cyp2c19*2*17 (intermediate metabolizers).   conclusion : the cyp2c19*17 genetic distribution in iranian population is similar to middle east or european countries. the high frequency of cyp2c19*17 in iranian population highlights the importance of this new variant allele in metabolism of cyp2c19 substrates. thus, future association studies are required to reveal clinical consequence of this genetic polymorphism in carrier individuals.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Genotype and allele frequency of CYP2C19*17 in a healthy Iranian population

  Background: Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 ...

متن کامل

Genotype and allele frequency of CYP2C19*17 in a healthy Iranian population

BACKGROUND Cytochrome P450 2C19 (CYP2C19) is important in metabolism of wide range of drugs. CYP2C19*17 is a novel variant allele which increases gene transcription and therefore results in ultra-rapid metabolizer phenotype (URM). Distribution of this variant allele has not been well studied worldwide. The aim of present study was to investigate allele and genotype frequencies of CYP2C19*17 in ...

متن کامل

Allele Frequency of CYP2C19 Gene Polymorphisms in a Healthy Iranian Population

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...

متن کامل

Allele and Genotype Frequency of IL28B (rs12979860) in South Iranian population

Hepatitis C virus (HCV) has chronically infected million peoples worldwide. Spontaneous viral clearance occurs in 25% of affected patients. The standard regimen to treat HCV infection is the combination of pegylated interferon and ribavirin.1 The most important indicator of successful treatment is sustained virologic response (SVR), which is defined as undetectable HCV RNA 24 weeks after treatm...

متن کامل

Allele Frequency of CYP2C19 Gene Polymorphisms in a Healthy Iranian Population

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and interethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic responses and adverse drug reactions may vary from one person to another. In this study ...

متن کامل

allele and genotype frequency of il28b (rs12979860) in south iranian population

hepatitis c virus (hcv) has chronically infected million peoples worldwide. spontaneous viral clearance occurs in 25% of affected patients.  the standard regimen to treat hcv infection is the combination of pegylated interferon and ribavirin.

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۲۹، شماره ۱، صفحات ۸۷۲-۹۸۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023